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Research Studies

By pursuing both clinical and registry studies, the Chicago Cardiology Institute strives for excellence in patient care and innovation in technology used for the diagnosis and treatment of cardiovascular and peripheral vascular disease. A registry study is a type of research study that does not test any treatment and will not change a patient’s treatment in any way, as opposed to a clinical study in which patients are assigned different treatments.

Our current research studies focus on treatment of chronic total occlusion of the coronary artery and distal outflow peripheral arterial disease.

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Chronic Total Occlusion Study

Outcomes, Patient Health Status, and Efficiencies in Chronic Total Occlusion (Open CTO)

The goal of this registry study is to learn more about how patients feel a year after undergoing a percutaneous coronary intervention procedure (or PCI) for chronic total occlusion, a blockage in the heart vessel that is often referred to as “CTO.”

The study will be coordinated and sponsored by Saint Luke’s Hospital Mid-America Heart Institute in Kansas City, Missouri. A total of 1,000 patients nationwide will be enrolled in the registry. During the study, we will interview the patients throughout their hospital stay and document any observations.

Alexian Brothers Medical Center and the Chicago Cardiology Institute will be participating in this research/registry.

Biotronik Study

Biotronik: Protego DF4 Posat Approval Registry

The purpose of this study is to evaluate the overall safety of the Protego DF4 Leads for implantable cardiac devices over an event-free rate of five years.
West Suburban Medical Center and Chicago Cardiology Institute will be participating in this research study.

St Jude Medical Study

St Jude Medical: Safety and Cost Effectiveness of Same Day Discharge After Implantable Cardioverter-Defibrillator Implant Versus Next Day Discharge

The purpose of this study is to determine whether it is safe to send patients home from the hospital on the same day following an implantable cardioverter defibrillator (ICD) implant.
West Suburban Medical Center and Chicago Cardiology Institute will be participating in this research study.

LIBERTY 360° Study

LIBERTY 360° Prospective, Observational, Multi-Center Clinical Study to Evaluate Acute and Long Term Clinical and Economic Outcomes of Endovascular Device Intervention in Patients with Distal Outflow Peripheral Arterial Disease (PAD)

The purpose of this study is to evaluate endovascular device interventions in treating distal outflow peripheral artery disease (PAD) with critical limb ischemia (CLI) and/or intermittent claudication.

The primary objectives are:

Analyze the acute and long term clinical and economic outcomes of procedures performed to treat cases of distal outflow PAD that involve a target lesion located within 10 cm above the medial epicondyle to the digital arteries.
Develop the LIBERTY Plaque Burden Score to provide additional guidance for future interventions and to predict clinical outcomes.

Additionally, we will aim to create a universal classification schema that describes the distribution and plaque burden—including calcium—for disease in distal outflow PAD.